The report on updated evidence for pancreatic cancer was published as part of our Continuous Update Project in 2012.
The research team at Imperial College London produced the updated systematic literature review (SLR) of the evidence on food, nutrition and physical activity relating to the prevention of pancreatic cancer in 2011. The CUP review included 79 new papers that were identified in the CUP updated search.
The Expert Panel considered the updated evidence and for the first time decided to group several individual anthropometric exposures together according to their biological significance, which allowed a single conclusion to be drawn. These groupings were as follows:
‘Body fatness’ which the Panel interpreted to be reflected by BMI, abdominal girth and adult weight gain.
‘Greater childhood growth’ to reflect factors relating to development and maturation in childhood and adolescence, marked by BMI at aged about 20 years and adult attained height.
The Panel agreed that the updated CUP findings confirmed or strengthened the evidence that 'body fatness' and 'greater childhood growth' are a cause of pancreatic cancer.
The Pancreatic Cancer 2012 Report updates the pancreatic cancer section of the Second Expert Report (section 7.6) and is based on the findings of the 2011 SLR and the CUP Expert Panel discussion in June 2012.
Conclusions from the updated evidence for pancreatic cancer
The Panel's judgements are shown below. Further details on other factors can be found in the Pancreatic Cancer 2012 Report. Information on how the Panel judged the evidence can be found in Appendix 1 of the report, and further details in chapter 3 of the Second Expert Report.
Published findings in peer-reviewed journals
Selected findings from the pancreatic cancer CUP update have been published in peer-reviewed journals. Details of the papers and links to the abstract in PubMed are below:
Height and pancreatic cancer risk: a systematic review and meta-analysis of cohort studies. Aune D, Vieira AR, Chan DS, Navarro-Rosenblatt DA, Vieira R, Greenwood DC, Cade JE, Burley VJ & Norat T. Cancer Causes Control. 2012; 23(8): 1213-22. Abstract.
Dietary fructose, carbohydrates, glycemic indices and pancreatic cancer risk: a systematic review and meta-analysis of cohort studies. Aune D, Chan DS, Vieira AR, Navarro-Rosenblatt DA, Vieira R, Greenwood DC, Cade JE, Burley VJ & Norat T. Ann Oncol. 2012; 23(10): 2536-46. Abstract.
Body mass index, abdominal fatness and pancreatic cancer risk: a systematic review and non-linear dose-response meta-analysis of prospective studies. Aune D, Greenwood DC, Chan DS, Vieira R, Vieira AR, Navarro-Rosenblatt DA, Cade JE, Burley VJ & Norat T. Ann Oncol. 2011; 23(4): 843-52. Abstract.