Colorectal (bowel) cancer

The report on updated evidence for colorectal cancer was published in 2011.

Latest evidence

The systematic literature review (SLR) of evidence on food, nutrition and physical activity in relation to colorectal cancer is currently being updated and the Continuous Update Project’s independent Expert Panel will discuss the evidence in 2016.

The research team at Imperial College London produced the previous SLR of the evidence on food, nutrition, physical activity and preventing colorectal cancer in 2010. This review was for our Continuous Update Project (CUP) and included 263 new research papers.

The Expert Panel considered the updated evidence and agreed that the updated CUP findings confirmed or strengthened the convincing and probable conclusions of the Second Expert Report for colorectal cancer. The Panel agreed that the evidence for a protective effect from foods containing dietary fibre had strengthened could be upgraded to convincing. Conclusions for other factors previously judged to be convincing or probable were confirmed.

The Colorectal Cancer 2011 Report updates the colorectal cancer section of the Second Expert Report (section 7.9) and is based on the findings of the 2010 SLR and the Expert Panel discussion.

Conclusions from the updated evidence for colorectal cancer

The Expert Panel's judgements are shown below. Information on how the Panel judged the evidence can be found in Appendix 1 of the report, and further details in chapter 3 of the Second Expert Report.

Food nutrition, physical activity, and cancers of the colon and the rectum 2011

Published findings in peer-reviewed journals

Selected findings from the colon and rectum cancer CUP update have been published in peer-reviewed journals. Details of the papers and links to the abstract in PubMed are below:

Red and processed meat intake and risk of colorectal adenomas: a systematic review and meta-analysis of epidemiological studies.
Aune D, Chan DS, Vieira AR, Navarro Rosenblatt DA, R Vieira, Greenwood DC, Kampman E & Norat T. 
Cancer Causes Control. 2013; 24(4): 611-27. Abstract.

Carbohydrates, glycaemic index, glycaemic load, and colorectal cancer risk: a systematic review and meta-analysis of cohort studies. 
Aune D, Chan DS, Lau R, Vieira R, Greenwood DC, Kampman E & Norat T. 
Cancer Causes Control. 2012; 23(4): 521-535. Abstract.

Recent evidence for colorectal cancer prevention through healthy food, nutrition, and physical activity: Implications for recommendations. Perera PS, Thompson RL & Wiseman MJ.
Curr Nutr Rep. 2012 DOI 10.1007/s13668-011-0006-7. Abstract.

Dairy products and colorectal cancer risk: a systematic review and meta-analysis of cohort studies. 
Aune D, Lau R, Chan DS, Vieira R, Greenwood DC, Kampman E & Norat T. 
Ann Oncol. 2012; 23(1): 37-45. Abstract.

Meta-analyses of vitamin D intake, 25-hydroxyvitamin D status, vitamin D receptor polymorphisms and colorectal cancer risk. 
Touvier M, Chan DS, Lau R, Aune D, Vieira R, Greenwood DC, Kampman E, Riboli E, Hercberg S & Norat T. 
Cancer Epidemiol Biomakers Prev. 2011; 20(5): 1003-16. Abstract.

Nonlinear reduction in risk for colorectal cancer by fruit and vegetable intake based on meta-analysis of prospective studies. 
Aune D, Lau R, Chan DS, Vieira R, Greenwood DC, Kampman E & Norat T. 
Gastroenterology 2011; 141(1): 106-18. Abstract.

Red and processed meat and colorectal cancer incidence: meta-analysis of prospective studies. 
Chan DS, Lau R, Aune D, Vieira R, Greenwood DC, Kampman E & Norat T. 
PLoS ONE. 2011; 6: e20456. Abstract.

Dietary fibre, whole grains, and risk of colorectal cancer: systematic review and dose-response meta-analysis of prospective cohort studies. 
Aune D, Chan DSM, Lau R, Vieira R, Greenwood DC, Kampman E & Norat T. 
BMJ 2011; 343:d6617 Nov 10. Abstract.